CD34+ Humanized Mice

Humanized CD34+ mice are supreme in vivo models to study immunology, infectious diseases, and more. For example, NSG™engrafted models offer the longest research span, over 12 months with a functional human immune system displaying T-cell dependent inflammatory responses with no donor cell immune reactivity towards the host.

Hu-CD34+ mice produced by injecting CD34+ hematopoietic stem cells (hu-CD34) demonstrate robust multi-lineage engraftment of human immune cell populations including very good T cell maturation and function for long-term studies. JAX has been the pioneer of developing cutting-edge immunodeficient strains such as the NSG™ models and its variants to enable powerful research.

Key features:

• Human CD34+ cells stably engraft the bone marrow.
• Engraftment is stable for over one year without graft-versus-host disease.
• CD4+ and CD8+ T cells are present in circulation and other tissues (Shultz et al. 2005).
• With the hu-IL15, you can test the efficacy of NK-cell mediated therapeutics, including ADCC
• Hu-CD34 NSG models are ideally suited for testing therapeutics with antigen-independent T cell MOA.
• CD34+ hu-NSG-SGM3 are best for therapeutics with T cell and myeloid cell dependent MOA, including those that target AML