Antibody Drug Discovery

Antibody therapeutics have revolutionized modern medicine, offering highly specific and effective treatments for a wide range of diseases. At The Jackson Laboratory, we provide cutting-edge transgenic mouse models, including the Atlas™ platform, to accelerate monoclonal, bispecific, and multispecific antibody discovery.

Speak to an Expert

Atlas™ Full Human Diversity Mouse for Monoclonal Antibody Discovery

Thoughtfully designed to overcome many of the challenges with legacy technologies.

• Engineered knock-in of full diversity, human variable heavy and kappa light chains into endogenous mouse loci
• Selected variable regions comprise >99% of commonly expressed human sequences
• Incorporates only functional heavy and kappa light chain domains to promote optimal B-cell rearrangement

Learn More about Full Human Diversity

Atlas™ Binary Fixed Light Chain Mouse for Bispecific and Multispecific Antibody Discovery

Designed to enable the creation of bispecific and multispecific therapies that mimic native antibody structures.

• Generates antibodies allowing pairing of heavy and light chains without linkers, fusions, or modifications
• Supports target-driven selection from one of two fixed light chains in the context of a full diversity heavy chain
• Allows for improved diversity and hit recovery through optionality of two fixed kappa light chain pairings

Learn More about Binary Fixed Light Chain

The Jackson Laboratory and AbTherx

Our partnership with AbTherx combines decades of expertise in transgenic model development with advanced antibody discovery technologies, helping researchers generate antibodies with the diversity, affinity, and developability needed for successful therapeutic applications. Explore our innovative solutions to streamline drug discovery and bring life-saving treatments to patients faster.