CD34+ Humanized NSG-SGM3-IL15 Mice

Females

Overview

The JAX NSG-SGM3-IL15 (S-15) mouse model is the hemizygous product following the mating of the NSG-SGM3 and NSG-IL15 strains. Following human CD34+ hematopoietic stem cell engraftment, the S-15 mouse supports the differentiation of high levels of CD3+/CD4+ T cells, CD33+ myeloid progenitors, CD14+ monocytes, and CD56^dim+/CD16+ mature natural killer cells in a singular model. This offers a highly translatable humanized mouse model for researchers to evaluate various therapeutic indications and mechanisms of action. Off-the-shelf female human CD34+ HSC engrafted mice are available at 13-18 weeks of age.

Key Benefits

• CD34+ engrafted S-15 mice express CD4+, CD8+, and regulatory T cells.
• CD34+ engrafted S-15 mice express CD33+ myeloid cells, CD14+ monocytes, and CD56^dim+/CD16+ mature natural killer cells.
• Readily engraftable with human cancer cell line derived and patient derived xenograft for preclinical therapeutic studies.

Research Applicatons