New mutation vs. remutation
New gene mutations
New spontaneous mutations are genetically mapped and tested for allelism with other mutations that map to the same chromosomal region. If a new mutation is not allelic with any previously described mutation, it is considered a new gene mutation.
These new mutations provide valuable information about gene function and many may also provide new models of human genetic disorders.
Remutation
If a new mutation occurs in the same gene in which other mutations have previously been described, it is considered a remutation. Remutations are a valuable aid in cloning genes identified by spontaneous mutations. They also often provide a means to assess the phenotypic effects of different types or locations of mutations in a gene.
If the phenotype of mice with the remutation differs from the phenotype of the original mutation, or if the remutation occurs on a preferred genetic background, embryos or germplasm are preserved. The remutation stock may be maintained as a breeding colony as well, depending on demand.
